Publications

Articles

  1. Q.L. Nguyen, K. Hees, S. Hernandez Penna, F. König, M. Posch, M. Bofill Roig, E.L. Meyer, M.M. Freitag, T. Parke, M. Otte, H.-P. Dauben, T. Mielke, C. Spiertz, P. Mesenbrink, M. Gidh-Jain, S. Pierre, S. Morello, B. Hofner (2024). "Regulatory Issues of Platform Trials: Learnings from EU-PEARL". Clinical Pharmacology & Therapeutics. 1-12. DOI 10.1002/cpt.3244.

  2. Q. Nguyen, K. Hees, B. Hofner (2023). "Adaptive platform trials: the impact of common controls on type one error and power". Journal of Biopharmaceutical Statistics. 1-18. DOI 10.1080/10543406.2023.2275765.

  3. A. Mayr, T. Wistuba, J. Speller, F. Gude, B. Hofner (2023). "Linear or smooth? Enhanced model choice in boosting via deselection of base-learners". Statistical Modelling. 23(5-6):441-455. DOI 10.1177/1471082X231170045.

  4. B. Hofner, E. Asikanius, W. Jacquet, T. Framke, K. Oude Rengerink, L. Aguirre Dávila, M. Grünewald, F. Klinglmüller, M. Posch, F.P. Leacy, T. Lang, A. Koch, J. Zinserling, K. Roes (2023). "Vaccine Development during a Pandemic: General Lessons for Clinical Trial Design". Statistics in Biopharmaceutical Research. 1-13. DOI 10.1080/19466315.2023.2211538.

  5. I. Papadouli, J. Mueller-Berghaus, C. Beuneu, S. Ali, B. Hofner, F. Petavy, K. Tzogani, A. Miermont, K. Norga, O. Kholmanskikh, T. Leest, M. Schuessler-Lenz, T. Salmonson, C. Gisselbrecht, J. Llinares Garcia, F. Pignatti (2020). "EMA Review of Axicabtagene Ciloleucel (Yescarta) for the Treatment of Diffuse Large B-Cell Lymphoma". The Oncologist. 25:894-902. DOI 10.1634/theoncologist.2019-0646

  6. O. Collignon, C. Gartner, A.-B. Haidich, R.Hemmings, B. Hofner, F. Pétavy, M. Posch, K. Rantell, K. Roes, A. Schiel (2020). "Current statistical considerations and regulatory perspectives on the planning of confirmatory basket, umbrella and platform trials". Clinical Pharmacology & Therapeutics. 107:1059-1067. DOI 10.1002/cpt.1804.

  7. J.-H. Trösemeier, S. Rudorf, H. Loessner, B. Hofner, C. Kamp (2020). "Modellentwicklung und maschinelles Lernen erhöhen die Proteinausbeute". Biospektrum. 26:262-264. DOI 10.1007/s12268-020-1369-3.

  8. T. Richter-Heitmann*, B. Hofner*, F.-S. Krah, J. Sikorski, P. Wüst, B. Bunk, S. Huang, K. Regan, D. Berner, R. Boeddinghaus, S. Marhan, D. Prati, E. Kandeler, J. Overmann, M. Friedrich (2020). "Stochastic Dispersal Rather Than Deterministic Selection Explains the Spatio-Temporal Distribution of Soil Bacteria in a Temperate Grassland". Frontiers in Microbiology. 11:1391.DOI 10.3389/fmicb.2020.01391.

  9. R. Fietkau, M. Hecht, B. Hofner, D. Lubgan, H. Iro, O. Gefeller, C. Rödel, M.Hautmann, O. Kölbl, A. Salay, C. Rübe, P. Melchior, P. Breinl, W. Krings, S. Gripp, B. Wollenberg, R. Keerl, U. Schreck, B. Siekmeyerm, G. Grabenbauer, P. Balermpas, for the PacCis-Study Group (2020). "Randomized phase-III-trial of concurrent chemoradiation for locally advanced head and neck cancer comparing dose reduced radiotherapy with paclitaxel/cisplatin to standard radiotherapy with fluorouracil/cisplatin: The PacCis-trial" Radiotherapy and Oncology, 144:209-217. DOI 10.1016/j.radonc.2020.01.016.

  10. C. Weniger, A. Fujak, B. Hofner, M. Fuchs, R. Forst, R. Richter (2019). "Long-term Results of Conservative Therapy of Adolescent Idiopathic Scoliosis Using the Cheneau Brace". Klinische Pädiatrie, 231:248-254.
    DOI 10.1055/a-0963-8996.

  11. G. Casalicchio, J. Bossek, M. Lang, D. Kirchhoff, P. Kerschke, B. Hofner H. Seibold, J. Vanschoren, B. Bischl (2019). "OpenML: An R Package to Connect to the Networked Machine Learning Platform OpenML". Computational Statistics, 34:977-991. DOI 10.1007/s00180-017-0742-2.
    (Full text, view only).

  12. J.-H. Trösemeier, S. Rudorf, H. Loessner, B. Hofner, A. Reuter, T. Schulenborg, I. Koch, I. Bekeredjian-Ding, R. Lipowsky, C. Kamp (2019). "Optimizing the dynamics of protein expression". Scientific Reports. 9:7511(2019). DOI 10.1038/s41598-019-43857-5.

  13. G. Rauch, J. Röhmel, J. Gerß, A. Scherag, B. Hofner (2019). "Aktuelle Herausforderungen bei der Bewertung von Ethikanträgen - Aspekte der Digitalisierung und Personalisierung im Gesundheitswesen". Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 62(6):758-764. DOI 10.1007/s00103-019-02955-5.

  14. K. Blankenbach, N. Schwab, B. Hofner, O. Adams, B. Keller-Stanislawski, C. Warnke (2019). "Natalizumab-associated progressive multifocal leukoencephalopathy in Germany". Neurology. 92(19): e2232-e2239. DOI 10.1212/WNL.0000000000007451.

  15. A. Smith, B. Hofner, J. Lamb, J. Osenkowski, T. Allison, G. Sadoti, S. McWilliams, P. Paton (2019). "Modeling spatiotemporal abundance of mobile wildlife in highly variable environments using boosted GAMLSS hurdle models". Ecology and Evolution. 9:2346-2364. DOI 10.1002/ece3.4738.

  16. A. Mayr, L. Weinhold, B. Hofner, S. Titze, O. Gefeller, M. Schmid (2018). "The betaboost package - a software tool for modelling bounded outcome variables in potentially high-dimensional epidemiological data". International Journal of Epidemiology. 47:1383-1388. DOI 10.1093/ije/dyy093.

  17. E.-M. Stelzer, S. Book, E. Graessel, B. Hofner, J. Kornhuber, K. Luttenberger (2018). "Bouldering psychotherapy reduces depressive symptoms even when general physical activity is controlled for: a randomized controlled trial". Heliyon. 4(3):e00580. DOI 10.1016/j.heliyon.2018.e00580.

  18. J. Thomas, A. Mayr, B. Bischl, M. Schmid, A. Smith, B. Hofner (2018). "Gradient boosting for distributional regression - faster tuning and improved variable selection via noncyclical updates". Statistics and Computing. 28:673-687. DOI 10.1007/s11222-017-9754-6.
    (Full text, view only)

  19. A. Mayr, B. Hofner (2018). "Boosting for statistical modelling - a non-technical introduction". Statistical Modelling: An International Journal. 18: 365-384. DOI 10.1177/1471082X17748086.

  20. O. Gefeller, B. Hofner, A. Mayr, E. Waldmann (2017). Editorial: "Predictive Modelling Based on Statistical Learning in Biomedicine". Computational and Mathematical Methods in Medicine. 2017, Article ID 4041736, 1-3. DOI 10.1155/2017/4041736.

  21. P. Bahrmann, T. Bertsch, E. Giannitsis, M. Christ, B. Hofner, R. Christenson, B. Lindahl, C. Mueller (2017). "Quantification of renal function and cardiovascular mortality in patients admitted to the emergency department with suspected acute coronary syndromes: results from the TRAPID-AMI study".
    Clinical Laboratory, 63:1457-1466. DOI 10.7754/Clin.Lab.2017.170326"

  22. A. Mayr, B. Hofner, E. Waldmann, T. Hepp, O. Gefeller, M, Schmid (2017). "An update on statistical boosting in biomedicine". Computational and Mathematical Methods in Medicine. 2017, Article ID 6083072, 1-12. DOI 10.1155/2017/6083072.

  23. S. Friedrichs, J. Manitz, P. Burger, C.I. Amos, A. Risch, J.C. Chang-Claude, H.E. Wichmann, T. Kneib, H. Bickeböller, B. Hofner (2017). "Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies". Computational and Mathematical Methods in Medicine, 2017, Article ID 6742763, 1-17. DOI 10.1155/2017/6742763.

  24. I. Dörfler, J. Müller, M. Gossner, B. Hofner, W. Weisser (2017). "Success of a deadwood enrichment strategy in production forests depends on stand type and management intensity". Forest Ecology and Management, 400, 607-620. DOI 10.1016/j.foreco.2017.06.013.

  25. M. Burow, R. Forst, J. Forst, B. Hofner, A. Fujak (2017). "Perioperative complications of scoliosis surgery in patients with Duchenne muscular dystrophy and spinal muscular atrophy, focussing on wound healing disorders". International Journal of Neuroscience, 127(6):479-485. DOI 10.1080/00207454.2016.1196688.
    (Abstract, PDF)

  26. P. Bahrmann, M. Christ, B. Hofner, A. Bahrmann, S. Achenbach, C. Sieber, T. Bertsch (2016). "Prognostic value of different biomarkers for cardiovascular death in unselected older patients in the emergency department". European Heart Journal: Acute Cardiovascular Care, 5:568-578. DOI 10.1177/2048872615612455.

  27. B. Hofner, A. Mayr, M. Schmid (2016). "gamboostLSS: An R Package for Model Building and Variable Selection in the GAMLSS Framework". Journal of Statistical Software, 74(1):1-31. DOI 10.18637/jss.v074.i01.
    (Abstract, PDF)

  28. A. Mayr, B. Hofner, M. Schmid (2016). "Boosting the discriminatory power of sparse survival models via optimization of the concordance index and stability selection". BMC Bioinformatics, 17:288. DOI 10.1186/s12859-016-1149-8.
    (PDF)

  29. S. Engel, A. Reiter-Jäschke, B. Hofner (2016). "EduKation demenz®: Psychoedukatives Schulungsprogramm für Angehörige von Menschen mit Demenz". Zeitschrift für Gerontologie und Geriatrie, 49:187-195. DOI 10.1007/s00391-016-1034-0.

  30. B. Hofner, M. Schmid, L. Edler (2016). "Reproducible research in statistics: A review and guidelines for the Biometrical Journal". Biometrical Journal, 58:416-427. DOI 10.1002/bimj.201500156.
    (Abstract, PDF)

  31. B. Hofner, T. Kneib, T. Hothorn (2016). "A Unified Framework of Constrained Regression". Statistics and Computing, 26:1-14. DOI 10.1007/s11222-014-9520-y.

  32. R. Belli, A. Petschelt, B. Hofner, J. Hajto, S. Scherrer, U. Lohbauer (2016). "Fracture rates and lifetime estimations of CAD/CAM all-ceramic restorations". Journal of Dental Research. 95, 67-73. DOI 10.1177/0022034515608187.

  33. B. Hofner, L. Boccuto and M. Göker (2015). "Controlling false discoveries in high-dimensional situations: Boosting with stability selection". BMC Bioinformatics, 16:144. DOI 10.1186/s12859-015-0575-3
    (Abstract, PDF)

  34. P. Bahrmann, A. Bahrmann, B. Hofner, M. Christ, S. Achenbach, C. Sieber, T. Bertsch (2015). "Multiple biomarker strategy for improved diagnosis of acute heart failure in older patients presenting to the emergency department." European Heart Journal: Acute Cardiovascular Care, 4:137-147. DOI 10.1177/2048872614541904
    (Abstract, PDF)

  35. S. Letz, C. Haag, E. Schulze, K. Frank-Raue, F. Raue, B. Hofner, B. Mayr, C. Schöfl (2014). "Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia". PLoS ONE, 9(12): e115178, DOI 10.1371/journal.pone.0115178.

  36. B. Balzien, B. Hofner, E. Harlander-Weikert, P. Frommelt, H. Bork, R. Forst, A. Fujak (2014). "Orthopädische Beschwerden und Funktionseinschränkungen beim Post-Polio-Syndrom" (English Title: Musculoskeletal Symptoms in Patients with Post-Polio Syndrome). Z Orthop Unfall, 152:241-246.
    (Abstract, PDF)

  37. M. d. C. Montero-Calasanz, B. Hofner, M. Göker, M. Rohde, C. Spröer, K. Hezbri, M. Gtari, P. Schumann, H.-P. Klenk (2014). "Geodermatophilus poikilotrophi sp. nov., a multi-tolerant actinomycete isolated from dolomitic marble." BioMed Research International, 2014(914767):1-11.
    (Abstract, PDF)

    • Dedicated software package: lethal now available on R-forge.

  38. B. Hofner, A. Mayr, N. Robinzonov, M. Schmid (2014). "Model-based Boosting in R: A Hands-on Tutorial Using the R Package mboost". Computational Statistics, 29:3-35.
    (Abstract, PDF)

  39. L. A. I. Vaas, J. Sikorski, B. Hofner, A. Fiebig, N. Buddruhs, H.-P. Klenk, M. Göker (2013). "opm: An R Package for Analysing OmniLog® Phenotype MicroArray Data". Bioinformatics, 29: 1823-1824.
    (Abstract, PDF)

    • Dedicated software package: opm now available on CRAN.

  40. B. Hofner, T. Hothorn, T. Kneib (2013). "Variable Selection and Model Choice in Structured Survival Models". Computational Statistics, 28:1079-1101.
    (Abstract, PDF)

  41. K. Luttenberger, B. Hofner, E. Graessel (2012). "Are the effects of a non-drug multimodal activation therapy of dementia sustainable? Follow-up study 10 months after completion of a randomised controlled trial". BMC Neurology, 12:151.
    (Abstract and PDF)

  42. A. Mayr, N. Fenske, B. Hofner, T. Kneib, M. Schmid (2012). "Generalized additive models for location, scale and shape for high dimensional data - a flexible approach based on boosting." Journal of the Royal Statistical Society, Series C (Applied Statistics), 61:403-427.
    (Abstract, PDF)

    • Dedicated software package: gamboostLSS now available on CRAN.

  43. A. Mayr, B. Hofner, M. Schmid (2012). "The importance of knowing when to stop - a sequential stopping rule for component-wise gradient boosting". Methods of Information in Medicine, 51:178-186.
    (Abstract, PDF)

  44. C. P. Schneider, J. Fertmann, J. Miesen, H. Wolf, C. Flexeder, B. Hofner, H. Küchenhoff, K.-W. Jauch, W. H. Hartl (2012). "Short-term prognosis of critically ill surgical patients: The impact of duration of invasive organ support therapies." Journal of Critical Care, 27:73-82.
    (Abstract, PDF)

  45. B. Hofner, T. Hothorn, T. Kneib, M. Schmid (2011). "A Framework for Unbiased Model Selection Based on Boosting". Journal of Computational and Graphical Statistics, 20:956-971.
    (Abstract, PDF, Supplements)

  46. B. Hofner, J. Müller, T. Hothorn (2011). "Monotonicity-Constrained Species Distribution Models". Ecology, 92:1895-1901.
    (Abstract, PDF, Supplements)

  47. K. Bayerlein, T. Kraus, I. Leinonen, D. Pilniok, A. Rotter, B. Hofner, J. Schwitulla, W. Sperling, J. Kornhuber, T. Biermann (2011). "Orexin A expression and promoter methylation in patients with alcohol dependence comparing acute and protracted withdrawal". Alcohol, 45:541-547.
    (Abstract)

  48. A. Tzschoppe, E. Struwe, W. Rascher, H. Dörr, R. Schild, T. Goecke, M. Beckmann, B. Hofner, J. Kratzsch, J. Dötsch (2011). "Intrauterine growth restriction (IUGR) is associated with increased leptin synthesis and binding capability in neonates". Clinical Endocrinology, 74:459-466.
    (Abstract, PDF)

  49. B. Hofner, T. Kneib, W. Hartl, H. Küchenhoff (2011). "Building Cox-Type Structured Hazard Regression Models with Time-Varying Effects." Statistical Modelling: An International Journal, 11:3-24.
    (Abstract, PDF)

  50. T. Hothorn, P. Bühlmann, T. Kneib, M. Schmid, B. Hofner (2010). "Model-based Boosting 2.0". Journal of Machine Learning Research, 11:2109-2113
    (Abstract, PDF)

  51. C. P. Schneider, J. Fertmann, S. Geiger, H. Wolf, H. Biermeier, B. Hofner, H. Küchenhoff, K.-W. Jauch, W. H. Hartl (2010). "Long-term survival after surgical critical illness: the impact of prolonged organ support therapy." Annals of Surgery, 251(6):1145-1153.
    (Abstract)

    • This mauscript was awarded with the Georg Heberer Award 2011 (ger, en).

  52. C. P. Schneider, C. Seyboth, M. Vilsmaier, H. Küchenhoff, B. Hofner, K.-W. Jauch, W. H. Hartl (2009). "Prognostic factors in critically ill patients suffering from secondary peritonitis: a retrospective observational survival time analysis." World Journal of Surgery, 33:34-43.
    (Abstract, PDF)

  53. P. Moubarak, S. Zilker, H. Wolf, B. Hofner, T. Kneib, H. Küchenhoff, K.-W. Jauch, W. H. Hartl (2008). "Activity-guided antithrombin III therapy in severe surgical sepsis: Efficacy and safety according to a retrospective data analysis". Shock, 30:634-641.
    (Abstract)

  54. J. Fertmann, H. Wolf, H. Küchenhoff, B. Hofner, K.W. Jauch KW, W.H. Hartl (2008). "Prognostic factors in critically ill surgical patients requiring continuous renal replacement therapy." Journal of Nephrology, 21:909-918.
    (Abstract)

Book Review

  • B. Hofner (2012). Book Review: "Biostatistical Design and Analysis Using R: A Practical Guide. Logan (2010)." Biometrical Journal, 54:437-438.
    (Article)

Books / Book chapters

  • F. Otto-Sobotka, R. Mirkov, B. Hofner, T. Kneib (2021). "Modeling flow in gas transmission networks using shape-constrained expectile regression". Daouia, A., Ruiz-Gazen, A. (eds) Advances in Contemporary Statistics and Econometrics, pp. 261-280. Springer, Cham. DOI: 10.1007/978-3-030-73249-3_14

  • B. Hofner, A. Smith (2015). "Boosted negative binomial hurdle models for spatiotemporal abundance of sea birds". In H. Friedl, H. Wagner (eds.) Proceedings of the 30th International Workshop on Statistical Modelling, pp. 221-226. Linz, Austria.
    (PDF)

  • A. Mayr, B. Hofner, M. Schmid (2015). "Boosting the discriminatory power of survival models via the C-index and stability selection". In H. Friedl, H. Wagner (eds.) Proceedings of the 30th International Workshop on Statistical Modelling, pp. 296-301. Linz, Austria.

  • C. Benhamda, A. Benkahla, S. Ben Miled, H. Ouled-Haddar, M.d.C. Montero-Calasanz, M. Gtari, A. Cherif, B. Hofner, K. Ghedira, H. Sghaier (2015). "The RadioP1: An Integrative Web Resource for Radioresistant Prokaryotes", Evolution of Ionizing Radiation Research, Dr. Mitsuru Nenoi (Ed.), InTech.
    (Abstract, PDF)

  • F. Sobotka, R. Mirkov, B. Hofner, P. H. C. Eilers, T. Kneib (2012). "Modeling flow in gas transmission networks using shape-constrained expectile regression". In A. Komárek and S. Nagy (eds.) Proceedings of the 27th International Workshop on Statistical Modelling, pp. 315-320. Prague, Czech Republic.

  • A. Mayr, N. Fenske, B. Hofner,T. Kneib, M. Schmid (2011). "Boosting Generalized Additive Models for Location, Scale and Shape". In D. Conesa, A. Forte, A. Lopez-Quilez and F. Munoz (eds.) Proceedings of the 26th International Workshop on Statistical Modelling, pp. 384-389. Valencia, Spain.

    • Best student paper award of the IWSM 2011 was awarded to A. Mayr for this work.

  • B. Hofner (2011). "Boosting in Structured Additive Models". Dissertation, LMU München. Verlag Dr. Hut, München. (Abstract and PDF)

Other documents (not peer-reviewed)

  • B. Hofner (2018). "Boosting methods for complex biological and biomedical applications". Habilitationsschrift. Available upon request.

  • B. Hofner*, L. Vaas*, J.-P. Lawo, T. Müller, J. Sikorski, D. Repsilber (2012). "Biologists meet statisticians: A workshop for young scientists to foster interdisciplinary team work". Technical Report, arXiv:1208.5597v1.

    * equal contributions

  • B. Hofner, F. Scheipl (2016). Guidelines for Code and Data Submission: Speciffc Guidance on Reproducible Research (RR). URL http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4036/homepage/RR_Guideline.pdf

  • B. Hofner (2008). "Variable Selection and Model Choice in Survival Models with Time-Varying Effects". Diplomarbeit, Ludwig-Maximilians-Universität München. (PDF)

External Resources

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